Image showing somatostatin biochemical pathway complete with target cell somatostatin receptor Somatostatin receptors are receptors for the ligand somatostatin , a small neuropeptide associated with neural signaling, particularly in the post-synaptic response to NMDA receptor co-stimulation/activation. Somatostatin is encoded by a CRE and is very susceptible to gene promoter region activation by transcription factor CREB .[ 1]
There are five known somatostatin receptors:[ 2] Alzheimer's disease .[ 3]
All are G protein-coupled seven transmembrane receptors .
References
^ Lou L (2016). Principles of Neurobiology . New York, NY: Garland Science, Taylor and Francis Group. pp. 109– 110. ISBN 978-0-8153-4494-0 . ^ Hoyer D, Bell GI, Berelowitz M, Epelbaum J, Feniuk W, Humphrey PP, O'Carroll AM, Patel YC, Schonbrunn A, Taylor JE (1995). "Classification and nomenclature of somatostatin receptors" . Trends Pharmacol. Sci . 16 (3): 86– 8. doi :10.1016/S0165-6147(00)88988-9 PMID 7792934 . ^ Nilsson P, et al. Somatostatin receptor subtypes 1 and 4 regulate neprilysin, the major amyloid-β degrading enzyme in brain. Journal of Alzheimer’s Disease 2025; 109 (2): 651. doi :10.1177/13872877251392782
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